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It protects our cells from oxidative stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 165.Canivenc-Lavier M.C., Bennetau-Pelissero C

Our results are also consistent with publications showing that CAV-1 reduction upregulates angiogenesis-related factors as evidenced by an inverse correlation between CAV-1 and VEGF in osteosarcoma 28 , increased CXCR12 expression in CAV-1 silenced fibroblast 29 , and a significant negative correlation between osteopontin and caveolin-1 levels in human osteoarthritic cartilage 30

It typically points to one of two underlying mechanisms: infiltrating neoplasia or edema (often driven by an inflammatory response)

doi: 10.1530/JOE-18-0316, 227
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