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Erastin was first discovered as an inducer of iron-dependent cell death called ferroptosis accompanied by antioxidant depletion caused by cystine glutamate antiporter inhibition

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Cats and dogs possess a combined repertoire of at least 27 cytosolic glutathione transferases belonging to the GST-A, -M, -P, -T, -Z and -O classes, with the greatest genetic diversity observed for the GSTA, GSTM, GSTP, and GSTT classes