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doi: 10.1016/j.freeradbiomed.2013.02.008

A standard approach is to add the drug to the agar plate to a given concentration
Exacerbations should be treated using a high dosage targeted antibiotic therapy,3,4 due to the fact that the volume of distribution and total body clearance for hydrophilic drugs (such as aminoglycosides, penicillins, and cephalosporins) are increased because these patients are generally undernourished and have decreased adipose tissue

Missed doses are skipped rather than doubled

However, randomized control trials with large samples are rare

However, certain populations exhibit higher rates due to founder effects or consanguinity patterns that increase mutation frequency within families or communities
