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Safety and feasibility of ketone supplementation The neuroprotective effect of ketones was first established over a century ago through the treatment of epilepsy with a ketogenic diet [106]

61 In the context of myocardial I/R injury, the Wnt pathway is engaged in various I/R-associated processes, including apoptosis, 78 inflammatory responses, oxidative stress, ECM remodeling, angiogenesis, cardiac hypertrophy, and fibrosis

In other studies, phenytoin was used as a reagent to treat mouse embryos because it causes oxidation of DNA, proteins, and lipids, likely due to increased production of OH radicals (89, 90)

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We confirmed these proteomic results in individual immunoblotting experiments using Jurkat and HEK-293T cells (Fig