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Multi-week culture studies examining collagen, elastin, and proteoglycan gene expression often require repeat dosing of cultures across several passages, which draws down stock material more quickly than a single-endpoint assay

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Glucocorticoid Regulation of Inflammation and Its Functional Correlates: From HPA Axis to Glucocorticoid Receptor Dysfunction. Annals of the New York Academy of Sciences 1261: 5563

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it is a vital mediator of cellular aging and metabolic adaptation (77)