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The PUFA are necessary for the plasma membrane fluidity and normal physiological function

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Exogenous administration of neurotrophic factors can promote nerve regeneration and improve functional outcomes in experimental models of DPN

This process is completely abolished in 2 subunit knockout mice, confirming its role as the molecular basis of rewarding effects ( 4 2 -nAChRs, increasing their spontaneous discharge frequency and thereby augmenting inhibitory inputs to dopaminergic neurons