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Calculations are done in Python (3.14.6) with scipy (1.18.0), pythonmeta (1.26), numpy (2.5.0), statsmodels (0.14.6), and plotly (6.8.0)

Introduction Sulfur is an essential element that is incorporated into various cellular metabolites and used for multiple metabolic processes in fungi, including the proteogenic amino acids cysteine (Cys) and methionine (Met), oxidative stress defense [glutathione (GSH) and ergothioneine (EGT)], methylation [ S -adenosylmethionine (SAM)], epipolythiodioxopiperazine (ETP) toxin biosynthesis (e.g., gliotoxin) and iron metabolism (FeS clusters) ( Aspergillus fumigatus , can acquire sulfur either from inorganic or organic sources ( A

GSH is one of the most abundant reducing thiols present in the majority of cells, thus the GSSG conversion is very important reaction for maintaining high levels of GSH within the cell

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