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Increased levels of HIF1 were evident along the differentiation of monocytes into tissue macrophages and play a prominent role in the uptake of bacteria by macrophages under hypoxic conditions and expression of tumour necrosis factor (TNF) and nitric oxide (NO) through inducible NO synthetase (iNOS)

10.1242/jcs.018093 104 HarrisA

This process involves both molecular and morphological changes in the astrocytes, including increased expression of GFAP, vimentin and nestin, uptake of excitotoxic glutamate, protection from oxidative stress by the production of GSH, neuroprotection by release of adenosine, degradation of amyloid-beta peptides, facilitation of blood-brain barrier, increased formation of gap junctions between astrocytes, formation of scars and, in some cases release of inflammatory cytokines, including tumor necrosis factor- (TNF-), and production of ROS [3,35,38-40]

doi: 10.2340/actadv.v103.11643 4 Said-FernandezSLSanchez-DominguezCNSalinas-SantanderMAMartinez-RodriguezHGKubelis-LopezDEZapata-SalazarNAet al

Sawada Y, Tong Y, Barangi M, Hata T, Williams MR, Nakatsuji T, Gallo RL

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