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Additionally, some horse racing organizations have introduced regulations to limit or ban the use of furosemide due to concerns about its potential to mask other substances

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Additionally, higher levels of vascular endothelial growth factor, substance P, and platelet-derived endothelial cell growth factor are often detected in the bladder endothelium of IC patients compared to controls Notably, bladder epithelial cells in individuals with IC exhibit intrinsic alterations in differentiation, neurotransmitter release, potassium channel activity, increased nitric oxide production, nuclear factor-B activation, nerve fiber density, serum C-reactive protein levels, and the production of neuropeptide Y and nerve growth factor

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Duman et al., 2005

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