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human translation has been inconsistent (Kovalzon & Strekalova, 2006)

ADO activates A2A/A2B receptors, triggering cAMP-mediated immunosuppression

doi: 10.1111/ene.12297 189 RubegniA.BattistiC.TessaA.CeraseA.DocciniS.MalandriniA.et al

investigated the regulatory effect of epithalon on the production of melatonin and cortisol in senescent monkeys, finding that the peptide significantly stimulated melatonin synthesis, thus normalizing the circadian rhythm of cortisol secretion [11]

Generally, the induction of the type I IFN response targets different immune cells from antigen-presenting dendritic cells, T cells to natural killer (NK) cells (200)