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Moreover formulation (L-carnitine vs propionyl-/acetyl-L-carnitine), dose, route, timing relative to ischemia/reperfusion, and treatment duration of L carnitine (short peri-procedural courses vs chronic supplementation) may contribute to these differences (Da Silva Guimares et al

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Supplements should be viewed as adjuncts at most, not primary interventions

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Neurochem Int 47:5157 Kosenko E, Kaminsky Y, Kaminsky A et al (1997) Superoxide production and antioxidant enzymes in ammonia intoxication in rats