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This response, often characterized by a 'cytokine storm,' generates an enormous amount of reactive oxygen species

Cellular ROS levels were analyzed using a DCFA/H2DCFDA-cellular ROS assay kit (ab11385, Abcam) after treatment with RSL3 for 6 h following the manufacturers instructions

Non-heme manganese catalase-the other catalase

However, either by accident or for a purpose, the flow of electrons through the ETC is an imperfect process in which 0.4 to 4% of oxygen consumed by mitochondria is incompletely reduced and leads to the production of ROS such as superoxide anion ( O 2 ) designated as primary ROS [2, 43]

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P (2018) Oxidative stress, aging, and diseases

Histological evaluations revealed enhanced resistance to oxidative stress induced by hydrogen peroxide in a hybrid model involving MMTV-PyMT transgenic mice with metastatic breast cancer expressing the human catalase gene (mCAT)