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Reported observations in laboratory studies include measurable changes in cellular signaling markers , structural protein organization , and other assay-specific experimental endpoints

Then, we explored the relationship between sulindac-induced autophagy and apoptosis by combining treatment with sulindac and 3-MA (an autophagy inhibitor) or Z-VAD-FMK (an apoptosis inhibitor)

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Troubleshooting persistent nausea If nausea persists beyond the first 1-2 weeks at a given dose combination, consider reducing the most recently escalated compound by one dose level