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Because transdermal administration necessitates passing through the hydrophobic/lipophilic SC, absorption in the deep aqueous layers, and then passage into the systemic circulation, these substances also need to have a moderate lipophilicity/hydrophilicity balance (logP = 15) [73,150,153]
for 3 h and then concentrated under vacuum
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10.1016/j.neuint.2016.12.012 234
