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We use methylcobalamin, the biologically active form of B12 most readily utilized by the body, more effective than the cyanocobalamin found in most over-the-counter supplements, which requires conversion before the body can use it

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Interestingly, restoring fatty acid metabolism has been found to prevent tubulointerstitial fibrosis in mouse models of renal injury.26 Recent studies have demonstrated that upregulation of peroxisome proliferator-activated receptor (PPAR) plays a crucial role in renal hypertrophy,27 highlighting the importance of lipid metabolism on renal hyperplasia

That oversight is part of why sourcing matters so much

30 Three of the four RCTs of B12 alone used oral B12 (1000 g per day) and one used i.m

They lack the biological signal to move forward