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eLife 10 , e65215 (2021)

However, succinyl-CoA can also be generated through the catabolism of other amino acids, such as isoleucine, or the short-chain fatty acid propionate, produced by gut bacteria

As a result, the expression levels of KRT27 and KRT28 , which are essential for the proper assembly of type I and II keratin protein complexes and formation of keratin intermediate filaments in the IRS, were significantly higher in the KO group (Fig

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