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1,3 Angiogenesis inhibitors work by specifically recognizing and binding to VEGF so that VEGF is unable to activate the VEGF receptor to stimulate the growth of new blood vessels

doi: 10.1038/s41392-023-01588-0 246 DeMaioAMehrotraSSambamurtiKHusainS

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This leads to the conclusion that the damage to capillaries by ROS (which are fundamental to the development of diabetic retinopathy) is due to a paracrine mechanism, i.e

They were acclimatized for 7 days and fed with normal chow