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The area of immunoreactivity of IBA1, GFAP, 3-NT, and 8OHDG were semi-quantified using Fiji/ImageJ software

Br J Haematol 2009

Genes associated with adipogenesis and lipogenesis, including adiponectin, C1Q, and collagen domain containing ( ADIPOQ ), cluster of differentiation 36 ( CD36 ), FABP4 , fatty acid binding protein 5 ( FABP5 ), LPL , stearoyl-CoA desaturase ( SCD ), perilipin 1 ( PLIN1 ), cell death-inducing DNA fragmentation factor-like effector C ( CIDEC ), and peroxisome proliferator activated receptor ( PPARG ), as well as genes related to steroid biosynthesis, including 24-dehydrocholesterol reductase ( DHCR24 ), lanosterol synthase ( LSS ), methylsterol monooxygenase 1 ( MSMO1 ), NAD(P)-dependent steroid dehydrogenase-like ( NSDHL ), and cholesterol 25-hydroxylase ( CH25H ), were shown to be associated with high TG content in breast muscles [39]

Particular emphasis is placed on rational design principles that consistently enhance brain bioavailability and therapeutic efficacy across models of Alzheimers disease, Parkinsons disease, multiple sclerosis, and related disorders