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The degenerative process itself may deplete these resident progenitor pools, impair essential EMT processes required for cell migration, or hinder the ability of migrated cells to reach their target locations [39]

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However, subsequent well-designed, randomized, placebo-controlled clinical trials with NAC 600 mg three times daily, combined with other medications or in monotherapy failed to provide evidence supporting the use of NAC in patients with IPF [31] and identified safety issues with the combination of prednisone, azathioprine, and NAC [30]