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They report that a chaperone-dependent E3 ubiquitin ligase, STIP1 homology and U-Box containing protein 1 (STUB1) modulates TFEB content by preferentially ubiquitylating its phosphorylated form as a signal for degradation by the 26S proteasome

As a result, patients may suffer from classic hypothyroid symptoms but are often told their thyroid is normal. Thyroid Conversion Syndrome can mimic primary hypothyroidism, and in many cases, the symptoms are nearly indistinguishable without targeted testing

Dikalov SI, Ungvari Z

However, I am eating much cleaner this month (given my big race this weekend) and have stopped alcohol and most day travel