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The second goal of the article is to outline the therapeutic implications of peroxynitrite, and to give an overview of the various pharmacological classes of peroxynitrite scavengers and peroxynitrite decomposition catalysts

The mainly vesicular intracellular localization of MRP1 in STB and pFECs was puzzling given the fact that these drug transporters are generally considered to be cell surface localized and to mediate drug resistance by lowering total intracellular drug concentrations