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However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

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These findings consistently emphasize the importance of changes in the concentrations of various ions in the extracellular environment of neurons, and it is possible that targeting the concentrations of ions in the environment to permanently regulate the splicing of neurexins and thereby interfere with synaptic plasticity could be one of the mechanisms of sustained antidepressant effect