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Active MTORC1 inhibits autophagy by binding and phosphorylating the ULK complex composed of ULK1, ULK2 (unc-51 like autophagy activating kinase 2), and ATG13 (autophagy related 13) proteins [170]

Published online February 4, 2025

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This synergy demonstrates that autophagy can serve as a cytoprotective mechanism in response to stress induced by bacteria in certain situations, and its inhibition leads to the rapid induction of apoptosis