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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Kim M.J., Seong K.-Y., Kim D.S., Jeong J.S., Kim S.Y., Lee S., Yang S.Y., An B.-S

Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses

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Hitting all three together is what produces synergistic effects on appetite, metabolic rate, and glucose control that single- and dual-agonists cant match

& Ciccarelli, O