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Billesblle CB, Azumaya CM, Kretsch RC et al (2020) Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Targeting one of the enzymes in the biosynthetic pathway to the ER allowed more time for spontaneous substrate rearrangement before enzymatic conversion, thereby improving titer and specificity for morphine

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PubMed, Eggers, Erika D., and Peter D