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Piper MD, Partridge L, Raubenheimer D, Simpson SJ (2011) Dietary restriction and aging: a unifying perspective

Both studies showed that the combined therapy had a synergistic impact, significantly reducing hepatic inflammatory markers such as leptin, TNF- , and IL-1, more than either intervention alone

55 Thus, it appears that relevant LPO sufficient to cause cell death is only observed under conditions that make the animals highly susceptible to LPO, but not under normal conditions

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