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Without enough B12, methylmalonic acid backs up and homocysteine climbs

These require immediate medical attention and discontinuation of the product
G., Yang, J., Santra, S., Santra, S., Chopp, M., & Morris, D

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However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels
