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In some cases, it can exert pro-oxidant effects, potentially worsening oxidative stress

And these are just the ones that have been studied

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Hepcidin expression in astrocytes regulates iron intake, which helps mitigate neuronal loss in the cortex and hippocampus of amyloid precursor protein/presenilin-1 (APP/PS1) mice (Xu et al., 2020

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In the absence of MAP3K7, p62 recruits and mediates the translocation of RIPK1 to the autophagosomal membrane, inducing necrosis by assembling the necrosis complex, and the death modality is converted to apoptosis when p62 is knocked out [89]
