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Clearance is the most important pharmacokinetic term to be considered in defining a rational steady-state drug dosage regimen

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Nat Cell Biol 10(12):14701476 Kanninen KM et al (2016) Exosomes as new diagnostic tools in CNS diseases

The macrocycle 23 was selected as a proper research tool for more detailed studies since the molecule is convenient to prepare and due to its structural similarity to the IRAP substrates oxytocin and vasopressin in its N-terminal

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