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However, the biotransformation of selenium into selenodiglutathione (GSSeSG) inside the vacuole does not contribute toward the reduction of its toxicity
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The importance of Nrf2 function is shown in an animal model in which the upregulation of Nrf2 will protect against dietary carcinogen diethylnitrosamine (DENA)-induced liver carcinogenesis [51]
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In addition, hyperosmolarity is associated increased expression of the SLC6A6 gene allowing for increased taurine uptake
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