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rather, it is synthesized in extragonadal sites such as breast, brain, muscle, bone, and adipose tissue where it acts locally as a paracrine or intracrine factor (8)

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This activation initiates a cascade of beneficial downstream effects: Increased Glucose Uptake: AMPK promotes the translocation of GLUT4 transporters to the cell membrane, particularly in skeletal muscle, enhancing the uptake of glucose from the bloodstream

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