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10.1007/s13311-012-0148-3 Neurotherapeutics

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Furthermore, as highlighted in the previous section regarding therapeutic strategies, the critical relationship between immunosenescence and inflammation has prompted clinical trials to investigate targeting macrophages (NCT01045512), endothelial cells (NCT04537884), and neutrophils (NCT02441205) (Table 2) in an effort to mitigate immunosenescence and combat conditions such as congestive heart failure, neovascular age-related macular degeneration, and diabetes

Vitamin C and zinc support immune function and tissue repair, while magnesium and vitamin D help regulate mood and stress

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The therapeutic efficacy of key polyphenolic compounds such as curcumin, resveratrol, EGCG, and quercetin has been supported by in vitro, in vivo, and emerging in silico studies that elucidate their target interactions and pharmacokinetics