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10.1016/j.freeradbiomed.2023.11.005

T.WilloughbyD.CarnegieG

In addition, 2-oxoglutarate may also serve as a transcriptional modulator via activation of 2-oxoglutarate oxygenase, which has several biological roles, including demethylation of histones and nucleic acids, and destabilization of transcriptional factor HIF-1 42

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