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Together, these results suggest that the worsened liver injury observed in FBXL5 CD11c mice is not attributable to increased hepatocellular ferroptosis but is instead likely due to elevated ferrous iron levels within CD11c + myeloid cells

Experimentally, this relationship has been verified in breast cancer patients with an r 2 of 0.6262 [30], supporting its use as a surrogate marker of low global GSH states in general

If it suffers one-electron reduction, there is formation of a very unstable semiquinone radical, which reacts rapidly with molecular oxygen resulting in regeneration of the parent compound and production of a superoxide anion that yields H 2 O 2 via enzymatic or spontaneous dismutation

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An imbalance between free radical production and antioxidant defence leads to an oxidative stress state, which may be involved in aging processes and even in some pathology (e.g

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