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doi:10.3389/fnut.2022.853846 Hidese S, Ogawa S, Ota M, et al

is supported by the NIH (NS112727 and AI144004)

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Notably, supplementation with 5-methyl-THF reversed longevity of long-lived mutants, of reduced insulin signaling (rIIS), inherently caloric restricted, and mitochondrial mutants, while folic acid supplementation did not alter lifespan of wt nematodes [63]

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Li, H., Ren, K., Jiang, T., & Zhao, G