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Inflammation-mediated inhibition of protein translation, increased sensitivity to nucleases and instability further limited clinical and therapeutic applications 19

Nitric oxide functions both as a signaling molecule in endothelial and nerve cells and as a killer molecule activated by immune cells

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Phospholipase A2 is overactivated during SAP, destroying pulmonary surfactant and inducing inflammation through accumulation of eicosanoids and platelet-activating factor [105]

Bone turnover markers: Osteocalcin (bone formation), CTX (bone resorption)