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However, research has not confirmed they are safe or effective for this purpose

Methods 12 , 523526 (2015)

Furthermore, mitochondrial damage is present early in disease course in TDP-43 A315T mice and increases motor neuron vulnerability (Gautam et al., 2019), consistent with dysregulation of the redox system early in neurodegeneration

All articles were considered, but those published between 2013 and 2019 were the focus of the review

Targeted metabolomics confirmed that GSH was downregulated after GDIL knockdown (Fig