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Hence, the tissues and cells should have molecular mechanisms to recover their active form, including the dihydroorotate dehydrogenase action in the IMM, causing pyrimidine biosynthesis and reducing ubiquinone through the oxidation of dihydroorotate to rotate

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Solvent A consisted of 94.9% (v/v) water, 5% (v/v) acetonitrile, and 0.1% (v/v) formic acid, and solvent B was composed of 5% (v/v) water, 94.9% (v/v) acetonitrile, and 0.1% (v/v) formic acid