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Effect of urate-elevating inosine on early parkinson disease progression: the SURE-PD3 randomized clinical trial

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Epub 2012 Oct 15

One study raised an interesting point: circadian clock-related gene expression may exist in the pituitary, and this expression is related to the expression of GH gene ( CLOCK gene and the BMAL1 gene was not high, which was consistent with the view that different parts of the circadian clock system linked to different functions as circadian oscillators ( CLOCK, PER1, PER2, CRY3, NRLD2 ) showed the difference of expression oscillation in the pituitary of GH transgenic and wild type coho salmon, which indicated that the GH gene might have a regulatory effect on the expression of pituitary clock genes

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Kreutzer FP, Meinecke A, Schmidt K, Fiedler J, Thum T (2022) Alternative strategies in cardiac preclinical research and new clinical trial formats