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-synuclein The nigrostriatal dopaminergic system suffers from neurodegeneration brought on by -synuclein, which is clinically evident as the usual PD/parkinsonian symptoms

CRISPR interference (CRISPRi) screens using dCas9-KRAB enable efficient and uniform repression of target genes with limited cellular toxicity 39,40 , whereas primary cortical culture 41,42 captures physiological aspects of human cortical neurogenesis, supporting sensitive detection of cell fate choices

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Hyperinflammation and airway surface liquid dehydration in cystic fibrosis: purinergic system as therapeutic target

Gasca-Salas C, Garca-Lorenzo D, Garcia-Garcia D, Clavero P, Obeso JA, Lehericy S, Rodrguez-Oroz MC (2019) Parkinsons disease with mild cognitive impairment: severe cortical thinning antedates dementia

Troubleshooting your loaf There are a few things that need to be considered when baking bread to ensure success