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Earlier studies with anti-inflammatory drugs have shown benefits in the treatment of major depressive disorder (MDD), but the effects are expected to be higher in patients with increased inflammatory activity

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Because Fe-S clusters function as essential cofactors for components of the electron transport chain, TCA cycle enzymes, and genome maintenance machinery, their stability depends on a reducing intracellular environment that is maintained, in part, by GSH 203,208

Dalle-Donne, I., et al.,S-glutathionylation in protein redox regulation

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