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T.WangD

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Methods This study was a case-cohort design nested within EPIC-Heidelberg

Coinhibition of GPX and Nrf2 also has a synergistic effect on ovarian cancer, which is particularly susceptible to ferroptosis due to its iron addiction. A study showed that combining Nrf2 inhibitors (e.g., ML385) with GPX4 inhibitors synergistically suppressed ovarian cancer by inducing ROS accumulation, lipid peroxidation, and caspase-3 activation, promoting ferroptosis and apoptosis

Drug Discov Today 12(56):218224

In this blog post, we'll be comparing four of the most popular