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1 Introduction Male infertility has become an increasingly serious health issue worldwide recently, which may involve around 2.5% -12% of the global male population ( SCs are widely present in embryos, fetuses, and adult tissues, which are a type of undifferentiated primitive cells with multipotent differentiation potential

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However, like any medical treatment, it is crucial to consult healthcare professionals for safe and personalized treatment

10.1371/journal.pone.0087235 PLoS One 54 UpadhyayS

Accelerated Growth of Pre-Existing Cancers IGF-1 may accelerate tumor progression, especially in tissues sensitive to hormonal or growth signaling (e.g., breast, prostate, colorectal)

Although low concentrations of NO are essential for motility and the capacitation process, high concentrations of NO can induce DNA damage in different ways [59]