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Those with thiamine and B12 shortages or malabsorption issues are best suited for this treatment

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There is no official link between moderately elevated B12 levels and specific symptomatology in most individuals

Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk