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Proceedings of the National Academy of Sciences 109.18 ( 2012 ): 6916-6921
Headaches and nerve pain are among the most common complaints linked to a deficiency

The medication should be injected subcutaneously into the abdomen, thigh, or upper arm, with rotation of injection sites to prevent lipodystrophy or persistent local reactions

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However, synthetic hydrogels may lack biocompatibility and can be toxic when certain polymers react, significantly limiting their use in medical treatments (Hu et al., 2025)
