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This instability begins at the molecular level and compounds through every production step
Stancu IC, Cremers N, Vanrusselt H, Couturier J, Kessels S, Lodder C, Brne B, Huaux F, Octave JN, Terwel D (2019) Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
Howard, Royce B

Uptake of extracellular asparagine prevents the death of glioblastoma cells in response to glutamine depletion by blocking the apoptotic function of a glutamine-induced endoplasmic reticulum stress marker protein, ATF4, and by increasing glutamate-ammonia ligase (GLUL)-mediated glutamine and protein synthesis 116,117

Author contributions PG designed the study and led the analysis

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