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The upper lobe is mostly -helical and contains the zinc binding site as well as the catalytically important residues

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Consistent with a neuroprotective function of TFG, its CRISPRi-mediated depletion in induced pluripotent stem cell (iPSC)-derived neurons led to increased damage upon LLOMe treatment, as assessed by higher numbers of mCherryGal3 puncta compared with control neurons (Extended Data Fig