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Few studies suggest that IGF-1 is upregulated in damaged muscle tissue and is associated with chronic pain conditions such as endometriosis, bone cancer, and orofacial pain 20,21

Nicotinic acid is a precursor in pyridine nucleotide synthesis, and an initial step in its conversion is nicotinamide synthesis in the liver

Investigate vitamin metabolism and distribution using stable isotope-labeled vitamins like B-complex derivatives

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and can increase the occurrence of kidney stones (Smets 2010)

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