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Remarkably, both human and mouse hepatocytes enlist these cell-autonomous immune programs to eliminate Plasmodium, with their pharmacologic or genetic inhibition leading to profound malarial susceptibility in vivo

Furthermore, ROS accumulation over time leads to irreversible damage, and Harman's (84) theory provides further insight into the role of extracellular ROS in triggering age-related cancer progression (85)

Tremors, bradykinesia, and postural instability manifest following a 7080% depletion of dopaminergic neurons in the substantia nigra (SN) [3] and subsequently, dopamine release in the striatum is impaired [4]

Individual treatment groups were: (1) DMSO vehicle control (0.0003%, corresponding to the DMSO concentration in the high BPA group), (2) water control, (3) 0.001 M (low) BPA, and (4) 0.1 M (high) BPA

10.1021/jm00171a013 J

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