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Together, these findings identify EAR-20 as a novel subunit-dependent positive allosteric modulator with the potential to inspire the development of small molecules targeting the same binding site, offering proof of concept for therapeutic strategies to treat neurological and neurodevelopmental disorders

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doi:10.1016/j.pep.2004.08.016

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Affected dogs may experience ongoing symptoms such as diarrhea, vomiting, weight loss, and reduced quality of life, often requiring long-term management

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